Cell and Molecular Biology

Paper Code: 
BOT 201
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Course Objectives: 

This course will enable the students to-

  1. To provide an overview of cell structure and function at the molecular level.
  2. To introduce some of the major ideas and experimental approaches in cell and molecular biology.

Course Outcomes (COs):

Course

Course Outcomes

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

BOT 201

 

Cell and Molecular Biology

On completion of this course, the students will be able to:

CO19: Apprehend the structure of basic components of prokaryotic and eukaryotic cells, especially membranes and organelles.

CO20: Explain energy generation and utilization by the cellular components

CO21: Illustrate and explain mechanism of mitotic and meiotic cell division.

CO22: Explain how DNA stores genetic information

CO23: Elucidate and describe the role of complementary base pairing in the precise replication process of DNA

Class lectures

Seminars

Tutorials

Group discussions and Workshops

Question Framing

 

Class test, Semester end examinations, Quiz, Solving problems in tutorials, Assignments, Presentation, Individual and group projects
 

 

 

9.00
Unit I: 
Cell organelles

Cell envelopes and organelles: Cell wall: structure, plasma membrane:  structure, models and functions, structure and function of chloroplast, mitochondria, golgi bodies, endoplasmic reticulum, lysosomes, plasmodesmata, vacuoles, ribosomes, biogenesis of chloroplast and mitochondria.

 

9.00
Unit II: 
Nuclear Organization

Nuclear Organization: Ultrastructure of nucleus, nuclear membrane, nucleolus, nuclear pores; Chromosome structure and packaging of DNA, specialized type of chromosome: Polytene and lampbrush chromosome, B chromosomes, Heterochromatin and Euchromatin, Barr bodies

 

9.00
Unit III: 
Cell Division

Cell Division: Amitosis, Mitosis, Meiosis.

Cell cycle: Phases of cell cycle, Cell cycle checkpoints, role of cyclins and cyclin dependent kinases.

 

 

9.00
Unit IV: 
DNA

DNA-The Genetic Material: DNA structure, A, B and Z forms; elementary idea of DNA damage and repair, DNA methylation; satellite and repetitive DNA, DNA replication, transcription and translation.

 

 

9.00
Unit V: 
RNA

RNA-The Genetic Material: Biogenesis, structure and its types- rRNA, mRNA, and tRNA, RNA processing (splicing of m RNA, rRNA and tRNA), RNA editing and transposons.

 

Essential Readings: 
  • Power, C. B. (2015). Cell Biology. Himalaya Publishing House.
  • A Text Book of Cell Biology and Genetics. 2021. Veer Bala Rastogi. Kedar Nath Ram Nath.
  • Verma, P. S., & Agarwal, V. K. (2010). Genetics. 9th revised multicolor edition. New Delhi: S. Chand.
  • Robertis, E. M. F. D. 8th edition. (2011). Cell and molecular biology. New York: Lippincott Williams & Wilkins.

 

References: 

Suggested Readings:

  • Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. Available from: https://www.ncbi.nlm.nih.gov/books/NBK21054/
  • Snustad, D. P., & Simmons, M. J. 7th edition. (2016). Principles of genetics. Hoboken, N.J. : John Wiley & Sons, Inc., [2016]
  • In Buchanan, B. B., In Gruissem, W., & In Jones, R. L. (2015). Biochemistry & molecular biology of plants.
  • Karp, G., Iwasa, J., & Marshall, W. F. 9th edition. (2020). Karp's cell and molecular biology: Concepts and experiments. Hoboken (N.J.): Wiley. Copyright 2020.
  • Kleinsmith, L.J. and Kish, V.M. (1995). Principles of Cell and Molecular Biology (2nd edition). Harper Collins College Publishers. New York, USA.
  • Lewin, B. 2009. 6th edition. Genes VII. Oxford University Press, New York.
  • Lodish, H. F. (2021). 9th edition. Molecular cell biology. New York: Macmillan International Higher Education, [2021]. ©2021
  • Nath, P., & International Symposium on Plant Molecular Biology. (2003). Molecular insight in plant biology. Enfield, NH: Science Publishers.
  • Wolfe, S. L. (1994). Molecular and cellular biology. Belmont, Calif: Wordsworth Publishing Co. California, USA.
  • Rost, T. L. (2006). Plant biology. Belmont: Thomson.
  • Wilson, J. H., & Hunt, T. 6th edition. (2014). Molecular biology of the cell: The problems book / John Wilson and Tim Hunt. New York: Garland.

e-Resources:

Journals:

  • Nature Cell Biology (Nature Research)
  • Journals of Molecular Biology (Elsevier)
  • Molecular Biology of the Cell (American Society for Cell Biology)
  • European Journals of Cell Biology (Elsevier)
  • Cellular and Molecular Life Sciences

 

Academic Year: 
2022-2023
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